President Rouhani and Italian Prime Minister Matteo Renzi were overseeing the signing ceremony of the bilateral cooperation documents by ministers and other high-ranking officials of their respective countries.
The agreements were mainly in the industrial fields including forestry, road and railways buildings, mining and other infrastructure, banking, insurance, health, agriculture and gas industry.
Additional economic contracts are scheduled to be signed on Tuesday which will reportedly amount to 18.4 billion dollars.
Prior to the signing of documents, Rouhani and Renzi held a meeting on promotion of Iran-Italy relations and discussed regional developments.
Earlier in the day, President Rouhani met Italian President Sergio Mattarella during which he said Iran is keen on expansion of cooperation in post-sanctions era, including joint venture investment, transfer of technology and manufacturing export-oriented products.
President Rouhani is scheduled to visit Vatican and meet Pope on Tuesday.
The four-day state visit, the first by an Iranian head of state after implementation of the nuclear Joint Comprehensive Plan of Action (JPCOA), will also take Rouhani and his delegation to Paris for expansion of bilateral ties with European countries after removal of anti-Iran sanctions.
Negotiations will focus on bilateral relations as well as regional developments as Iranian and European statesmen in Rome and Paris are scheduled to confer and sign agreements and contracts on energy, economic, industrial and trade relations.